What is the 1-Methyl-4-pyrazole boronic acid pinacol ester?

1-Methyl-4-pyrazole boronic acid pinacol ester is white to light yellow crystal powder, while it's Molecular Formula is C10H17BN2O2. white to light yellow crystal powder It is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.

What is the CAS number for 1-Methyl-4-pyrazole boronic acid pinacol ester?

The CAS number of 1-Methyl-4-pyrazole boronic acid pinacol ester is 761446-44-0.

What is the 1-Methyl-4-pyrazole boronic acid pinacol ester?

1-Methyl-4-pyrazole boronic acid pinacol ester is white to light yellow crystal powder, while it's Molecular Formula is C10H17BN2O2. white to light yellow crystal powder It is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.

What is the CAS number for 1-Methyl-4-pyrazole boronic acid pinacol ester?

The CAS number of 1-Methyl-4-pyrazole boronic acid pinacol ester is 761446-44-0.

Product classification

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761446-44-0

Q: What is 1-Methyl-4-pyrazole boronic acid pinacol ester (761446-44-0) used for?

1-Methyl-4-pyrazole boronic acid pinacol ester is an organic compound that serves as a versatile reagent in various chemical reactions. It is characterized by its ability to participate in Suzuki-Miyaura cross-coupling and transesterification reactions, making it a valuable component in the synthesis of complex organic molecules.InChI:InChI=1/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3

Product Name：1-Methyl-4-pyrazole boronic acid pinacol ester
Molecular Formula：C₁₀H₁₇BN₂O₂
Purity：99%
Molecular Weight：208.068

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Product Details;

CasNo： 761446-44-0

Molecular Formula： C₁₀H₁₇BN₂O₂

Appearance： white to light yellow crystal powder

Reliable factory customized supply 1-Methyl-4-pyrazole boronic acid pinacol ester 761446-44-0

Molecular Formula:C10H17BN2O2
Molecular Weight:208.068
Appearance/Colour:white to light yellow crystal powder
Vapor Pressure:0.001mmHg at 25°C
Melting Point:59-64 °C(lit.)
Refractive Index:1.505
Boiling Point:308.3 °C at 760 mmHg
PKA:2.09±0.10(Predicted)
Flash Point:140.3 °C
PSA：36.28000
Density:1.05 g/cm³
LogP:0.71930

1-Methyl-4-pyrazole boronic acid pinacol ester(Cas 761446-44-0) Usage

InChI:InChI=1/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3

761446-44-0 Relevant articles

Efficient salt-induced kinase inhibitor and preparation method thereof

-

, (2021/09/04)

The invention discloses an efficient sal...

AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF

-

Page/Page column 94, (2021/02/26)

Disclosed herein is an aminopyrazine com...

IMPROVED METHOD FOR THE MANUFACTURE OF 3-[(1S)-1-IMIDAZO[1,2-A]PYRIDIN-6-YLETHYL]-5-(1-METHYLPYRAZOL-4-YL)TRIAZOLO[4,5-B]PYRAZINE AND POLYMORPHIC FORMS THEREOF

-

Page/Page column 28-29, (2020/05/07)

This specification generally relates to ...

C-H Borylation Catalysts that Distinguish between Similarly Sized Substituents like Fluorine and Hydrogen

Miller, Susanne L.,Chotana, Ghayoor A.,Fritz, Jonathan A.,Chattopadhyay, Buddhadeb,Maleczka, Robert E.,Smith, Milton R.

supporting information, p. 6388 - 6392 (2019/08/26)

By modifying ligand steric and electroni...

761446-44-0 Process route

: 930-36-9
1-methyl-1H-pyrazole

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Conditions

Conditions	Yield
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In hexane; at 20 ℃; Glovebox; Inert atmosphere; With 4,4'-di-tert-butyl-2,2'-bipyridine; In hexane; at 20 ℃; Glovebox; Inert atmosphere; 1-methyl-1H-pyrazole; In hexane; at 20 ℃; for 5h; Reagent/catalyst; Solvent; Overall yield = 67 percent; regioselective reaction; Glovebox; Inert atmosphere;

Yield

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In hexane; at 20 ℃; Glovebox; Inert atmosphere;

With 4,4'-di-tert-butyl-2,2'-bipyridine; In hexane; at 20 ℃; Glovebox; Inert atmosphere;

1-methyl-1H-pyrazole; In hexane; at 20 ℃; for 5h; Reagent/catalyst; Solvent; Overall yield = 67 percent; regioselective reaction; Glovebox; Inert atmosphere;

: 847818-74-0
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Conditions

Conditions	Yield

761446-44-0 Upstream products

76-09-5
2,3-dimethyl-2,3-butane diol
847818-55-7
(1-methyl-1H-pyrazol-4-yl)boronic acid
269410-08-4
pyrazole-4-boronic acid pinacol ester
74-88-4
methyl iodide

761446-44-0 Downstream products

955369-19-4
1-methyl-4-(2-methyl-4-nitrophenyl)-1H-pyrazole
959909-79-6
4-(1-methyl-1H-pyrazol-4-yl)-2-nitroaniline
1020173-29-8
2-fluoro-3-methyl-4-[2-(1-methyl-1H-pyrazol-4-yl)-pyridin-4-yloxy]-phenylamine
1020173-31-2
2,3-difluoro-4-[2-(1-methyl-1H-pyrazol-4-yl)-pyridin-4-yloxy]phenylamine