956139-30-3

  • Product Name:Morpholino T subunit
  • Molecular Formula:
  • Purity:99%
  • Molecular Weight:609.062
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CasNo: 956139-30-3

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  • Molecular Formula:C31H34ClN4O5P
  • Molecular Weight:609.062

956139-30-3 Relevant articles

Lithium bromide-DBU mediated synthesis of chlorophosphoramidate-activated morpholino nucleoside subunits

Pattanayak, Sankha,Sinha, Surajit

, p. 6714 - 6717 (2013/01/15)

An efficient and rapid protocol for the ...

956139-30-3 Process route

1-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
914361-76-5

1-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

N,N-dimethylphosphoroamidic dichloride
677-43-0

N,N-dimethylphosphoroamidic dichloride

phosphoramidochloridic acid, N,N-dimethyl-, [6-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methyl ester
956139-30-3

phosphoramidochloridic acid, N,N-dimethyl-, [6-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methyl ester

Conditions
Conditions Yield
1-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium bromide; In dichloromethane; acetonitrile; at 0 ℃; for 0.0333333h; Inert atmosphere;
N,N-dimethylphosphoroamidic dichloride; In dichloromethane; acetonitrile; at 0 ℃; for 0.5h; Reagent/catalyst; Solvent; Temperature; Time; Inert atmosphere;
61%
phosphoramidochloridic acid, N,N-dimethyl-, [6-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methyl ester
956139-30-3

phosphoramidochloridic acid, N,N-dimethyl-, [6-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methyl ester

C<sub>81</sub>H<sub>136</sub>N<sub>4</sub>O<sub>10</sub>

C81H136N4O10

C<sub>112</sub>H<sub>169</sub>N<sub>8</sub>O<sub>15</sub>P

C112H169N8O15P

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1.5h; Inert atmosphere;
98%

956139-30-3 Upstream products

  • 914361-76-5
    914361-76-5

    1-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

  • 677-43-0
    677-43-0

    N,N-dimethylphosphoroamidic dichloride

956139-30-3 Downstream products

  • 1357354-80-3
    1357354-80-3

    C43H50N7O10P

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