27277-00-5
- Product Name：2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
- Molecular Formula：C9H13N5O
- Purity：99%
- Molecular Weight：207.235
Product Details;
CasNo： 27277-00-5
Molecular Formula： C9H13N5O
Appearance： White solid
Top quality factory supply 27277-00-5 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one at low price
- Molecular Formula:C9H13N5O
- Molecular Weight:207.235
- Appearance/Colour:White solid
- Vapor Pressure:1.22E-08mmHg at 25°C
- Melting Point:161.8-163 °C
- Refractive Index:1.696
- Boiling Point:459.9 °C at 760 mmHg
- PKA:2.96±0.40(Predicted)
- Flash Point:231.9 °C
- PSA：78.21000
- Density:1.44 g/cm3
- LogP:0.77280
2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one(Cas 27277-00-5) Usage
|
Flammability and Explosibility |
Notclassified |
|
Biological Activity |
Potent phosphodiesterase (PDE) 4 inhibitor (IC 50 = 35 nM for inhibition of [ 3 H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo . |
|
Biochem/physiol Actions |
Phosphodiesterase IV (PDE 4) inhibitor |
InChI:InChI=1/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12)
27277-00-5 Relevant articles
A triazole pyrimidone preparation method
-
Paragraph 0014; 0024-0047, (2019/04/04)
The invention belongs to the technical f...
A paraquat emetic and preparation method
-
Paragraph 0018-0040; 0042, (2019/04/04)
The invention relates to the field of or...
Technology for three-innovation synthesis of 2-amino-5-methyl-4-oxo-3-n-propyltriazolopyrimidine
-
Paragraph 0015; 0029-0040, (2019/11/29)
The invention discloses a technology for...
A preparation method of the emetic (by machine translation)
-
, (2019/04/17)
The invention relates to the field of or...
27277-00-5 Process route
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![2‐amino‐6‐methyl‐4H‐[1,2,4]triazolo[1,5‐a]pyrimidin‐5‐one](/upload/2026/4/772b2cad-46c7-4afa-b5af-08061c823f3a.png)
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27287-73-6
2‐amino‐6‐methyl‐4H‐[1,2,4]triazolo[1,5‐a]pyrimidin‐5‐one
-
-
106-94-5
propyl bromide
-
-
27277-00-5
ICI 63197
| Conditions | Yield |
|---|---|
|
With
sodium carbonate;
In
N,N-dimethyl-formamide;
at 105 ℃;
|
87.5% |
|
With
triethylamine;
In
chloroform;
at 65 ℃;
for 6h;
Concentration;
Solvent;
Temperature;
Reagent/catalyst;
|
85% |
|
With
potassium carbonate;
at 105 ℃;
|
68% |
-
![2-(benzylidene-amino)-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one](/upload/2026/4/db3e393a-2d4b-4850-b79f-43304add7bf1.png)
-
2-(benzylidene-amino)-6-methyl-4-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
-
-
27277-00-5
ICI 63197
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
water;
at 65 - 70 ℃;
for 0.5h;
Product distribution / selectivity;
Heating / reflux;
|
73% |
|
With
hydrogenchloride;
In
methanol; water;
at 20 ℃;
Product distribution / selectivity;
|
|
|
With
hydrogenchloride;
|
27277-00-5 Upstream products
-
27287-73-6
2‐amino‐6‐methyl‐4H‐[1,2,4]triazolo[1,5‐a]pyrimidin‐5‐one
-
106-94-5
propyl bromide
-
5848-26-0
N-n-propyl-N'-cyano-s-methylisothiourea
-
87253-78-9
3-amnio-5-n-propylamino-1,2,4-triazole
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