875302-45-7
- Product Name：DMT-2’-O-TBDMS-N1-methyl-Pseudouridine-CE-Phosphoramidite
- Molecular Formula：
- Purity：99%
- Molecular Weight：875.087
Product Details;
CasNo： 875302-45-7
Buy reliable Quality DMT-2’-O-TBDMS-N1-methyl-Pseudouridine-CE-Phosphoramidite 875302-45-7 raw material with Honest Price
- Molecular Formula:C46H63N4O9PSi
- Molecular Weight:875.087
875302-45-7 Relevant articles
NON-NATURAL RIBONUCLEOTIDES, AND METHODS OF USE THEREOF
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Page/Page column 123; 192, (2009/10/22)
One aspect of the present invention rela...
875302-45-7 Process route
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875302-41-3
5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine
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102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite
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875302-45-7
5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate
| Conditions | Yield |
|---|---|
|
With
2-(Dimethylamino)pyridine; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 4 - 6h;
Inert atmosphere;
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86% |
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875302-39-9
5'-O-(4,4'-dimethoxitrityl)-1-N-methylpseudouridine
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875302-45-7
5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine 3'-O-caynoethyl-N,N-diisopropylphosphoramidate
| Conditions | Yield |
|---|---|
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Multi-step reaction with 2 steps
1.1: pyridine; silver nitrate / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere
1.2: 3 - 4 h / 20 °C / Inert atmosphere
2.1: 2-(Dimethylamino)pyridine; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 - 6 h / 20 °C / Inert atmosphere
With
pyridine; 2-(Dimethylamino)pyridine; silver nitrate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
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875302-45-7 Upstream products
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875302-41-3
5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine
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102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite
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875302-39-9
5'-O-(4,4'-dimethoxitrityl)-1-N-methylpseudouridine
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40615-36-9
4,4'-dimethoxytrityl chloride
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