What is the (6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate?

(6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate is , while it's Molecular Formula is C37H37ClN5O5P. N,N-Dimethylphosphoramidochloridic Acid [(2S,6R)-6-[4-(Benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl Ester is an oligonucleotide analog having cationic intersubunit linkages for use in antisense modulation of gene expression. Also a potential antibacterial.

What is the CAS number for (6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate?

The CAS number of (6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate is 956139-21-2.

What is (6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate (956139-21-2) used for?

(6-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate is an oligonucleotide analog that features cationic intersubunit linkages. This unique structure allows it to be utilized in various applications, particularly in the realm of genetic research and medicine.

What is the (6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate?

(6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate is , while it's Molecular Formula is C37H37ClN5O5P. N,N-Dimethylphosphoramidochloridic Acid [(2S,6R)-6-[4-(Benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl Ester is an oligonucleotide analog having cationic intersubunit linkages for use in antisense modulation of gene expression. Also a potential antibacterial.

What is the CAS number for (6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate?

The CAS number of (6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate is 956139-21-2.

What is (6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate (956139-21-2) used for?

(6-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate is an oligonucleotide analog that features cationic intersubunit linkages. This unique structure allows it to be utilized in various applications, particularly in the realm of genetic research and medicine.

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956139-21-2

Product Name：Morpholino C subunit
Molecular Formula：
Purity：99%
Molecular Weight：698.158

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Product Details;

CasNo： 956139-21-2

Offer Chemical Raw Material Morpholino C subunit 956139-21-2 In Stock

Molecular Formula:C37H37ClN5O5P
Molecular Weight:698.158
PKA:8.63±0.20(Predicted)
Density:1.30±0.1 g/cm3(Predicted)

956139-21-2 Relevant articles

Diastereoselective Synthesis of Phosphorodiamidate Morpholino Dimers

Min, So Jeong,Kim, Na Young,Chae, Hyun Young,Chun, Keun Ho

supporting information, p. 252 - 253 (2020/02/20)

Lithium bromide-DBU mediated synthesis of chlorophosphoramidate-activated morpholino nucleoside subunits

Pattanayak, Sankha,Sinha, Surajit

, p. 6714 - 6717 (2013/01/15)

An efficient and rapid protocol for the ...

956139-21-2 Process route

: 125515-31-3
N-{1-[(2R,6)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl}benzamide

: 677-43-0
N,N-dimethylphosphoroamidic dichloride

: 956139-21-2
phosphoramidochloridic acid, N,N-dimethyl-, [6-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl ester

Conditions

Conditions	Yield
N-{1-[(2R,6)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl}benzamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium bromide; In dichloromethane; acetonitrile; at 0 ℃; for 0.0333333h; Inert atmosphere; N,N-dimethylphosphoroamidic dichloride; In dichloromethane; acetonitrile; at 0 ℃; for 0.416667h; Inert atmosphere;	74%
With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium bromide; In dichloromethane; acetonitrile; at 0 ℃; for 1h; Inert atmosphere;	60%

: 13089-48-0
N₄-benzoylcytidine

: 956139-21-2
phosphoramidochloridic acid, N,N-dimethyl-, [6-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium periodate / methanol / 0.17 h / 60 °C 1.2: 3 h / 60 °C 2.1: triethylamine / acetonitrile / 1 h / 0 °C 3.1: lithium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile; dichloromethane / 1 h / 0 °C / Inert atmosphere With sodium periodate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium bromide; In methanol; dichloromethane; acetonitrile;

Yield

Multi-step reaction with 3 steps

1.1: sodium periodate / methanol / 0.17 h / 60 °C

1.2: 3 h / 60 °C

2.1: triethylamine / acetonitrile / 1 h / 0 °C

3.1: lithium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile; dichloromethane / 1 h / 0 °C / Inert atmosphere

With sodium periodate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium bromide; In methanol; dichloromethane; acetonitrile;

956139-21-2 Upstream products

125515-31-3
N-{1-[(2R,6)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl}benzamide
677-43-0
N,N-dimethylphosphoroamidic dichloride
13089-48-0
N₄-benzoylcytidine
166239-52-7
C₁₆H₁₈N₄O₄*C₇H₈O₃S

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