635-46-1

  • Product Name:1,2,3,4-Tetrahydroquinoline
  • Molecular Formula:C9H11N
  • Purity:99%
  • Molecular Weight:133.193
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Product Details;

CasNo: 635-46-1

Molecular Formula: C9H11N

Appearance: clear pale yellow to yellow liquid

Quality Factory Supply 99% Pure 1,2,3,4-Tetrahydroquinoline 635-46-1 with Efficient Delivery

  • Molecular Formula:C9H11N
  • Molecular Weight:133.193
  • Appearance/Colour:clear pale yellow to yellow liquid 
  • Vapor Pressure:0.0212mmHg at 25°C 
  • Melting Point:9-14 °C(lit.) 
  • Refractive Index:n20/D 1.593(lit.)  
  • Boiling Point:250.775 °C at 760 mmHg 
  • PKA:5.09±0.20(Predicted) 
  • Flash Point:100.6 °C 
  • PSA:12.03000 
  • Density:1.006 g/cm3 
  • LogP:2.18270 

1,2,3,4-Tetrahydroquinoline(Cas 635-46-1) Usage

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 34, p. 3905, 1986 DOI: 10.1248/cpb.34.3905Tetrahedron, 52, p. 1631, 1996 DOI: 10.1016/0040-4020(95)00991-4

General Description

1,2,3,4-Tetrahydroquinoline is a bicyclic aromatic compound that serves as a substrate in enzymatic oxyfunctionalization reactions, yielding chiral synthons like (+)-(R)-1,2,3,4-tetrahydroquinoline-4-ol. It is also a key intermediate in hydrogenation processes, such as the selective reduction of quinoline using rhodium catalysts, and is utilized in the synthesis of heterocycles like epoxyisoindolo[2,1-a]quinolines and CETP inhibitors. Its derivatives exhibit potential pharmaceutical applications, including antihypoxic activity and modulation of lipid metabolism.

Definition

ChEBI: A member of the class of quinolines that is the 1,2,3,4-tetrahydro derivative of quinoline.

InChI:InChI=1/C9H11N/c1-2-6-9-8(4-1)5-3-7-10-9/h1-2,4,6,10H,3,5,7H2

635-46-1 Relevant articles

Correction to: Halogen-Bonding-Induced Hydrogen Transfer to C=N Bond with Hantzsch Ester (Org. Lett. (2014) 16:12 (3244-3247) DOI: 10.1021/ol501259q)

He, Wei,Ge, Yi-Cen,Tan, Choon-Hong

, p. 7684 - 7684 (2019)

The structure of C1 has been revised in ...

Medium-Sized-Ring Analogues of Dibenzodiazepines by a Conformationally Induced Smiles Ring Expansion

Costil, Romain,Lefebvre, Quentin,Clayden, Jonathan

, p. 14602 - 14606 (2017)

Analogues of dibenzodiazepines, in which...

Study of Hydrodesulfurization by the Use of 35S-Labeled Dibenzothiophene. 2. Behavior of Sulfur in HDS, HDO, and HDN on Sulfided Mo/Al2O3 Catalyst

Kabe, Toshiaki,Quian, Weihua,Ishihara, Atsushi

, p. 912 - 916 (1994)

To investigate the behavior of sulfur du...

-

Tsodikov et al.

, (1967)

-

Ru-decorated N-doped carbon nanoflakes for selective hydrogenation of levulinic acid to γ-valerolactone and quinoline to tetrahydroquinoline with HCOOH in water

Chauhan, Arzoo,Kar, Ashish Kumar,Srivastava, Rajendra

, (2022/03/27)

The effective dissociation of biomass-de...

Dehydrogenative and Redox-Neutral N-Heterocyclization of Aminoalcohols Catalyzed by Manganese Pincer Complexes

Brzozowska, Aleksandra,Rueping, Magnus,Sklyaruk, Jan,Zubar, Viktoriia

, (2022/03/17)

A new manganese catalyzed heterocyclizat...

Chemoselective and Tandem Reduction of Arenes Using a Metal–Organic Framework-Supported Single-Site Cobalt Catalyst

Antil, Neha,Kumar, Ajay,Akhtar, Naved,Begum, Wahida,Chauhan, Manav,Newar, Rajashree,Rawat, Manhar Singh,Manna, Kuntal

supporting information, p. 1031 - 1040 (2022/01/19)

The development of heterogeneous, chemos...

Aromatic compound hydrogenation and hydrodeoxygenation method and application thereof

-

Paragraph 0094-0095; 0114-0122, (2021/05/29)

The invention belongs to the technical f...

635-46-1 Process route

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quinoline

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1,2,3,4-tetrahydroisoquinoline
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1,2,3,4-tetrahydroisoquinoline

propylcyclohexane
1678-92-8

propylcyclohexane

phenylpropane
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phenylpropane

2-propylaniline
1821-39-2

2-propylaniline

Conditions
Conditions Yield
With hydrogen; ruthenium sulphide on HY-zeolite; In n-heptane; at 400 ℃; for 4.5h; under 25862.1 Torr; Product distribution; other catalysts;
1,4-dihydroquinoline
50624-35-6

1,4-dihydroquinoline

2-methyl-1,2-dihydroquinoline
1125-81-1

2-methyl-1,2-dihydroquinoline

1,2,3,4-tetrahydroisoquinoline
635-46-1

1,2,3,4-tetrahydroisoquinoline

2-Methyl-chinoliniumkation
42307-21-1

2-Methyl-chinoliniumkation

1,2,3,4-tetrahydro-2-methylquinoline
1780-19-4

1,2,3,4-tetrahydro-2-methylquinoline

Conditions
Conditions Yield
With methanol; hydrogenchloride; Product distribution; Mechanism; Ambient temperature; also with 6-methyl-1,2-dihydroquinoline substrate;

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