98796-53-3
- Product Name：DMT-dA(Bz)-CE-Phosphoramidite
- Molecular Formula：C47H52 N7 O7 P
- Purity：99%
- Molecular Weight：857.946
Product Details;
CasNo： 98796-53-3
Molecular Formula： C47H52 N7 O7 P
Factory supply good quality DMT-dA(Bz)-CE-Phosphoramidite 98796-53-3 with stock
- Molecular Formula:C47H52 N7 O7 P
- Molecular Weight:857.946
- Vapor Pressure:0-0Pa at 20-50℃
- PKA:7.87±0.43(Predicted)
- PSA：168.70000
- Density:1.23 at 20℃
- LogP:9.12618
5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite(Cas 98796-53-3) Usage
|
Physical form |
Powder or granules |
|
Color |
White to off-white |
InChI:InChI=1/C21H23NO3.C8H11NO2.C3H6N2O2P/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18;9-4-3-6-1-2-7(10)8(11)5-6;1-3(2-4)7-8(5)6/h1-10,16,19,24H,11-15H2;1-2,5,10-11H,3-4,9H2;3H,5H2,1H3/q;;-1
98796-53-3 Relevant articles
ON-DEMAND PHOSPHORAMIDITE SYNTHESIS
-
Page/Page column 36-38; 48, (2022/01/24)
The invention relates to a method of syn...
BICYCLIC PEPTIDE LIGAND STING CONJUGATES AND USES THEREOF
-
Paragraph 00549, (2020/08/28)
The present invention provides compounds...
Microwave-assisted preparation of nucleoside-phosphoramidites
Meher,Efthymiou,Stoop,Krishnamurthy
supporting information, p. 7463 - 7465 (2014/07/07)
Microwave-assisted phosphitylation of st...
Overcoming hydrolytic sensitivity and low solubility of phosphitylation reagents by combining ionic liquids with mechanochemistry
Hardacre, Christopher,Huang, Haifeng,James, Stuart L.,Migaud, Marie E.,Norman, Sarah E.,Pitner, William R.
supporting information; experimental part, p. 5846 - 5848 (2011/06/26)
Ionic liquids have been used in combinat...
98796-53-3 Process route
-
-
124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine
-
-
64325-78-6
N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine
-
-
98796-53-3
N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]
| Conditions | Yield |
|---|---|
|
N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
for 0.166667h;
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine;
With
1-hexyl-1-methylimidazoliumtris(pentafluoroethyl)trifluorophosphate;
for 1.75h;
|
92% |
|
With
N-ethyl-N,N-diisopropylamine;
for 0.5h;
Ionic liquid;
ball miling;
|
80% |
|
N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine;
With
dmap; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 15 ℃;
for 0.333333h;
Molecular sieve;
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine;
In
tetrahydrofuran;
at 15 ℃;
for 0.666667h;
|
61.2% |
|
In
tetrahydrofuran;
according to ref 3) with modifications;
|
|
|
With
N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
for 0.583333h;
Ambient temperature;
|
-
-
131420-63-8
2-O-cyanoethyl-N,N,N’,N’-tetraisopropylphosphordiamidite
-
-
64325-78-6
N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine
-
-
98796-53-3
N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]
| Conditions | Yield |
|---|---|
|
With
saccharin-N-methylimidazole salt;
at 20 ℃;
for 5 - 7h;
|
84% |
|
2-O-cyanoethyl-N,N,N’,N’-tetraisopropylphosphordiamidite; N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine;
In
acetonitrile;
for 0.0833333h;
With
saccharin-N-methylimidazole salt;
at 20 ℃;
for 18h;
|
75% |
98796-53-3 Upstream products
-
124482-92-4
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine
-
64325-78-6
N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine
-
102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite
-
174647-46-2
2-cyanoethoxy(N,N-diisopropylamino)3-nitro-1,2,4-triazolylphosphine
98796-53-3 Downstream products
-
119484-01-4
O-2-cyanoethyl 5'-O-dimethoxytrityl-N6-benzoyldeoxyadenosin-3'-yl phosphonate
-
23339-47-1
d(ApT)
-
863507-31-7
C56H57N8O14PS
-
262429-99-2
4-oxo-pentanoic acid 5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[{5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yloxy}-(2-cyano-ethoxy)-thiophosphoryloxymethyl]-tetrahydro-furan-3-yl ester
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